Lattice layered compounds
Magaldrate
Al5Mg10(OH)31(SO4)2 · x H2O
Magaldrate is a lattice layered, crystalline complex of magnesium aluminium hydroxysulphate. It has an exceptionally rapid reaction rate with gastric acid whilst maintaining the stomach pH in the optimum range of 3 - 5. The reaction rate is unaffected by the presence of proteins and pepsin. Magaldrate can adsorb large quantities of bile acids, preventing these aggressors from attacking the mucous membranes.
Magaldrate Powder C 410 / C 411
C410 / C411 are spray dried powders consisting of agglomerations of very fine primary crystals. These agglomerations are mainly spherical in nature, ensuring excellent flow characteristics.
These powder grades are found in the majority of magaldrate tablets in the market today.
| Type | C410 | C411 |
| Assay Al(OH)3 (200°C/4h) | 32,1 - 45,9 [%] | 32,1 - 45,9 [%] |
| Assay Mg(OH)2 (200°C/4h) | 49,2 - 66,6 [%] | 49,2 - 66,6 [%] |
| Density (tapped) | 0,4 - 0,6 [g/ml] | 0,6 - 0,8 [g/ml] |
| d50 | 15 - 30 µm | 20 - 35 µm |
| Pharmacopoeia | PhEur, USP | PhEur, USP |
Magaldrate Powder C 425
C425 is a milled magaldrate powder, ideal for the formulation of soft tablets and candies as well as for powder mixtures intended for resuspension, for example, powder sachets.
It is also possible to resuspend C425 for liquid formulations depending on process conditions and formulation requirements.
| Type | C425 |
| Assay Al(OH)3 (200°C/4h) | 32,1 - 45,9 [%] |
| Assay Mg(OH)2 (200°C/4h) | 49,2 - 66,6 [%] |
| Density (tapped) | 0,4 - 0,6 [g/ml] |
| d50 | 5 - 10 µm |
| Pharmacopoeia | PhEur, USP |
Magaldrate Suspension C 632
C 632 is a viscous paste with a magaldrate content of 20 – 25 %. The viscosity borders on the limit of flow capability. The paste is stable on storage and after transportation, displaying only slight sedimentation and no caking. C 632 is suitable for the production of both single and double strength formulations.
Other concentrations of C632 are available on demand.
| Type | C632 |
| Assay Al(OH)3 (200°C/4h) | 32,1 - 45,9 [%] |
| Assay Mg(OH)2 (200°C/4h) | 49,2 - 66,6 [%] |
| Viscosity (Brookfield) | max. 400 mPa s (LV 3/12) |
| d50 | 6 - 10 µm |
| Pharmacopoeia | USP |
Hydrotalcite
Al2Mg6(OH)16CO3 · x H2O
Hydrotalcite is a lattice layered, crystalline complex of magnesium aluminium hydroxycarbonate. It contains a higher proportion of magnesium than magaldrate. Hydrotalcite reacts rapidly with gastric acid even in the presence of pepsin and proteins.
Hydrotalcite Powder C 300
C 300 is a spray dried powder for use in all tablet formulations, preferably after pre-granulation.
A milled quality is available on request which is suitable for the formulation of soft tablets and candies or for resuspending for liquid formulations.
| Type | C300 |
| Assay Al2O3 | 15,3 - 18,7 [%] |
| Assay MgO | 36,0 - 44,0 [%] |
| Density (tapped) | 0,4 - 0,6 [g/ml] |
| d50 | 10 - 30 µm |
| Pharmacopoeia | BP |
Almagate
Al2Mg6(OH)14(CO3)2 · x H2O
Almagate is a crystalline compound similar to hydrotalcite. It reacts very rapidly with gastric acid even in the presence of pepsin and proteins.
Almagate Powder C 310
C310 is a spray dried powder with similar properties to hydrotalcite powder. It is suitable for the production of fast acting tablets.
Almagate Suspension C 610
C610 has an almagate content of ca. 16%. It is ideal for use in liquid antacid formulations.